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phenobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. CYP3A4 inducers may well raise the metabolism of ifosfamide to its Lively alkylating metabolites.Barbiturates are respiratory depressants, and the diploma of respiratory melancholy is dependent on the dose.NHP Biologicals fro